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GWAS results for 165 large breed dogs vs. 690 medium/small breed dogs.

(a) Family pedigree showing genotypes of LMNA variant. +/− heterozygous; N, clinically normal. (b) Sanger sequencing electropherograms of LMNA variant.

(b) Sequence chromatograms showing two mutations in the JAK1 gene. (c) Domain structure of the JAK1 protein. (d) JAK1 pseudokinase (JH2) and kinase (JH1) ...

S1 Fig. Summary of genetic investigations of X chromosome locus 1 provided by dog model, SNP chip and WGS data.

Species identification PCoA.

Outlier PCoA.

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Site-level PCoA.

Generalized dissimilarity modelling (GDM) results.

Morphological cladograms generated via maximum parsimony from a matrix of 13 ingroup plus three outgroup species

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Map of sampling sites and PCoA of genomic distance between samples.

Variation in seedling growth in chamber experiment.

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Variation in leaf traits in drought experiment.

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Mutation rate in peach II | Proceedings of the Royal Society of London B: Biological Sciences

Observed genotypes for the ten most strongly associated variants identified in large dogs using WGS data

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Owl genome during recent urbanization | Proceedings of the Royal Society of London B: Biological Sciences

Impact of Open Offices on Collaboration | Philosophical Transactions of the Royal Society B: Biological Sciences

Conservation of IRS4 mutated codons (in bold) between mammals.

Technical replicate dendrogram.

Variation in leaf shape.

Predicted spatial and temporal variation in genomic composition.

Functional studies of novel genes. a–c Expression of a AQP1, b ATP13A3 and c SOX17 mRNA in human pulmonary artery smooth muscle cells, pulmonary artery ...

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... of which 18 and 0.19 are rare ( <1% allele frequency), respectively. Error bars represent standard deviation. b, Breakdown of PTVs per individual ...

Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome ...

Best SNP markers associated with SBW above 41 kg in dogs.

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a, Proportion of validated de novo variants from two external data sets that are independently found in ExAC, separated by functional class and mutational ...

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Assessing association of a one-hit and two-hit model of NOD2 in the non-AJ

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a, Histograms of constraint Z scores for 18,225 genes. This measure of departure of number of variants from expectation is normally distributed for ...

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Training and knowledge transfer are also important steps those play an important role in the success of ERP implementation and ignorance or lack of ...

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